GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69026
Species: Homo sapiens
RGD Object: Gene
Symbol: PRKCD
Name: protein kinase C, delta
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that has formula C36H56O8.
CasRN: 16561-29-8
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDbisindolylmaleimide I affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKCD protein]

Go 6983 affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKCD protein]

2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide affects the reaction [Tetradecanoylphorbol Acetate affects the phosphorylation of PRKCD protein]

PMID:15380616
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]

PMID:18628248
affects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD protein

PMID:15976015
PMID:18628248
multiple interactionsEXP 6480464CTDTetradecanoylphorbol Acetate inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein]

PMID:11424089
decreases expressionEXP 6480464CTDTetradecanoylphorbol Acetate results in decreased expression of PRKCD protein

PMID:15949478
affects phosphorylationEXP 6480464CTDTetradecanoylphorbol Acetate affects the phosphorylation of PRKCD protein

PMID:15380616
increases phosphorylationEXP 6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein

PMID:15707588
increases activityISORGD:690276480464CTDTetradecanoylphorbol Acetate results in increased activity of PRKCD protein

PMID:10567579
increases localizationISORGD:690276480464CTDTetradecanoylphorbol Acetate results in increased localization of PRKCD protein

PMID:10656618
multiple interactionsISORGD:673836480464CTD1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]

calphostin C inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]

Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]

PMID:14678745
multiple interactionsISORGD:673836480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of and affects the localization of PRKCD protein

PMID:16361709
affects localizationISORGD:673836480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD protein

PMID:12755590
PMID:14678745
affects localizationISORGD:673836480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD protein

PMID:14678745
PMID:12755590
affects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD protein

PMID:18628248
PMID:15976015
affects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD protein

PMID:15976015
PMID:21705328
PMID:18628248
affects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD protein

PMID:21705328
PMID:15976015
PMID:18628248
increases phosphorylationEXP 6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein

PMID:15707588
PMID:20599481
PMID:21354279
multiple interactionsEXP 6480464CTD3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]

3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein]

PMID:20599481
affects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD protein

PMID:15976015
PMID:18628248
PMID:20599481
PMID:21705328
multiple interactionsEXP 6480464CTD5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]

PMID:22245252
multiple interactionsEXP 6480464CTDPRKCD protein affects the susceptibility to [Tetradecanoylphorbol Acetate co-treated with benz(a)anthracene]

[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]

PMID:22643241
affects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCD protein

PMID:15976015
PMID:18628248
PMID:20599481
PMID:21705328
PMID:22245252
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