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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68949
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il13
Name: interleukin 13
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il13decreases expressionEXP 6480464CTDOzone results in decreased expression of IL13 proteinPMID:30649513
Il13increases expressionEXP 6480464CTDOzone results in increased expression of IL13 proteinPMID:28623178 PMID:34051339
Il13decreases expressionISOIl13 (Mus musculus)6480464CTDOzone results in decreased expression of IL13 proteinPMID:28533327
Il13increases expressionISOIl13 (Mus musculus)6480464CTDOzone results in increased expression of IL13 mRNA; Ozone results in increased expression of IL13 proteinPMID:26282284 PMID:28891433 PMID:30090343 PMID:34285515
Il13increases response to substanceISOIl13 (Mus musculus)6480464CTDIL13 protein results in increased susceptibility to OzonePMID:18417511
Il13multiple interactionsISOIl13 (Mus musculus)6480464CTD[[TCRD protein affects the susceptibility to Dietary Fats] which affects the susceptibility to Ozone] which affects the expression of IL13 protein; [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of IL13 mRNA; [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of IL13 protein; [Air Pollutants results in increased abundance of Ozone] promotes the reaction [Ovalbumin results in increased expression of IL13 mRNA]; [Air Pollutants results in increased abundance of Ozone] promotes the reaction [Ovalbumin results in increased expression of IL13 protein]; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of IL13 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of IL13 protein; [alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]; [CPE affects the susceptibility to Ozone] which affects the expression of IL13 mRNA; [Dexamethasone inhibits the reaction [Ovalbumin co-treated with Ozone]] which results in increased expression of IL13 protein; [LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL13 protein; [Ovalbumin co-treated with Ozone] results in increased expression of IL13 protein; [Ozone co-treated with Ovalbumin] results in increased expression of IL13 mRNA; [Soot co-treated with Ozone] results in increased expression of IL13 mRNA; [Vehicle Emissions results in increased abundance of Ozone] which results in increased expression of IL13 mRNA; IL13 protein affects the reaction [Ozone results in increased expression of CCL20 protein]; IL13 protein affects the reaction [Ozone results in increased expression of CXCL1 mRNA]; IL13 protein affects the reaction [Ozone results in increased expression of IL6 protein]; IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL13 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]; Ozone inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]; Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]; Vitamin E inhibits the reaction [Ozone results in increased expression of IL13 protein]PMID:18417511 PMID:21355040 PMID:23434795 PMID:23747851 PMID:24188200 PMID:26203683 PMID:27472835 PMID:29284473 PMID:29499403 PMID:30090343 PMID:34146326 PMID:34760922 PMID:34911549 PMID:36303316
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