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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68942
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna1g
Name: calcium voltage-gated channel subunit alpha1 G
Acc ID: CHEBI:9434
Term: telmisartan
Definition: A member of the class of benzimidazoles used widely in the treatment of hypertension.
Chemical ID: MESH:C084178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna1gdecreases expressionEXP 6480464CTDtelmisartan results in decreased expression of CACNA1G mRNAPMID:19292980
Cacna1gmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]PMID:19292980
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