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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68404
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epas1
Name: endothelial PAS domain protein 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epas1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of EPAS1 mRNAPMID:22298810 PMID:34747641
Epas1affects expressionISOEpas1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of EPAS1 mRNAPMID:16962184 PMID:24058054 PMID:24680724
Epas1decreases expressionISOEpas1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of EPAS1 mRNAPMID:19933214 PMID:28213091
Epas1multiple interactionsISOEpas1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EPAS1 gene]PMID:28213091
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