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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68404
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epas1
Name: endothelial PAS domain protein 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epas1increases expressionISOEPAS1 (Homo sapiens)6480464CTDQuercetin results in increased expression of EPAS1 proteinPMID:17973296
Epas1multiple interactionsISOEPAS1 (Homo sapiens)6480464CTDferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]; Iron inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]PMID:17973296
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