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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68350
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr5a1decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of NR5A1 mRNA; Dibutyl Phthalate results in decreased expression of NR5A1 proteinPMID:17379624 PMID:21266533 PMID:32525071
Nr5a1multiple interactionsEXP 6480464CTDDibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP11A1 promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 binds to CYP17A1 promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 binds to STAR promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP11A1 promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 protein binds to CYP17A1 promoter]; Dibutyl Phthalate inhibits the reaction [NR5A1 protein binds to STAR promoter]PMID:17884934 PMID:23358192
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