GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pla2g4a | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA | PMID:23583884 PMID:34747641 | Pla2g4a | multiple interactions | EXP | | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA] | PMID:23583884 | Pla2g4a | affects expression | ISO | Pla2g4a (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of PLA2G4A mRNA | PMID:26377647 | Pla2g4a | affects response to substance | ISO | Pla2g4a (Mus musculus) | 6480464 | CTD | PLA2G4A protein affects the susceptibility to Tetrachlorodibenzodioxin | PMID:29043426 | Pla2g4a | increases expression | ISO | Pla2g4a (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA; Tetrachlorodibenzodioxin results in increased expression of PLA2G4A protein | PMID:17942748 PMID:19933214 PMID:21964420 PMID:22430074 PMID:23994337 PMID:30790002 PMID:32044341 | Pla2g4a | increases expression | ISO | PLA2G4A (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA | PMID:18938131 PMID:19162293 | Pla2g4a | increases phosphorylation | ISO | Pla2g4a (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of PLA2G4A protein | PMID:30790002 | Pla2g4a | increases phosphorylation | ISO | PLA2G4A (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased phosphorylation of PLA2G4A protein | PMID:25797602 | Pla2g4a | multiple interactions | ISO | Pla2g4a (Mus musculus) | 6480464 | CTD | AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of PLA2G4A protein]; arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PLA2G4A protein]; orientin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A protein]; PLA2G4A protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; PLA2G4A protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; PLA2G4A protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]; PLA2G4A protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; PLA2G4A protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PLIN2 protein]; PLA2G4A protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PLA2G4A promoter] | PMID:19063610 PMID:19282623 PMID:29043426 PMID:30790002 PMID:32044341 | Pla2g4a | multiple interactions | ISO | PLA2G4A (Homo sapiens) | 6480464 | CTD | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of PLA2G4A protein]; [Nifedipine co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; AHR affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [PLA2G4A protein results in increased secretion of Arachidonic Acid]]; arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; EGTA acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; methyl arachidonylfluorophosphonate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]; Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of PLA2G4A protein | PMID:18938131 PMID:19162293 PMID:25797602 | | ||||||||||||||||||||||
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