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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631409
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90aa1
Name: heat shock protein 90 alpha family class A member 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90aa1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of HSP90AA1 mRNAPMID:16815819
Hsp90aa1decreases expressionISOHSP90AA1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of HSP90AA1 mRNAPMID:27068294
Hsp90aa1increases expressionISOHSP90AA1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of HSP90AA1 mRNA; sodium arsenite results in increased expression of HSP90AA1 proteinPMID:12119132 PMID:12760830 PMID:23699174 PMID:26535918 PMID:28595984 PMID:30137596 PMID:30460075 PMID:36586010
Hsp90aa1increases expressionISOHsp90aa1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of HSP90AA1 mRNAPMID:16014739 PMID:30097599
Hsp90aa1multiple interactionsISOHSP90AA1 (Homo sapiens)6480464CTDCARM1 mutant form promotes the reaction [sodium arsenite results in increased expression of HSP90AA1 mRNA]; HSP90AA1 protein promotes the reaction [sodium arsenite results in increased phosphorylation of ERBB2 protein]; PRMT1 mutant form promotes the reaction [sodium arsenite results in increased expression of HSP90AA1 mRNA]PMID:23699174 PMID:30137596
Hsp90aa1multiple interactionsISOHsp90aa1 (Mus musculus)6480464CTD[sodium arsenite co-treated with Dietary Fats] results in increased expression of HSP90AA1 mRNAPMID:30097599
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