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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631365
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nampt
Name: nicotinamide phosphoribosyltransferase
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Namptdecreases expressionISONAMPT (Homo sapiens)6480464CTDBerberine results in decreased expression of NAMPT proteinPMID:26712469
Namptmultiple interactionsISONAMPT (Homo sapiens)6480464CTD[Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein]PMID:26712469
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