GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abca1 | multiple interactions | EXP | | 6480464 | CTD | [Cholesterol co-treated with 25-hydroxycholesterol] results in decreased expression of ABCA1 mRNA | PMID:17526932 | Abca1 | increases expression | ISO | Abca1 (Mus musculus) | 6480464 | CTD | 25-hydroxycholesterol results in increased expression of ABCA1 mRNA | PMID:19260826 | Abca1 | multiple interactions | ISO | ABCA1 (Homo sapiens) | 6480464 | CTD | [25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA; [25-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 protein; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA] | PMID:12595494 PMID:16023994 | | ||||||||||||||||||||||
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