Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca1decreases expressionISOABCA1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of ABCA1 proteinPMID:24165878
Abca1increases expressionISOABCA1 (Homo sapiens)6480464CTDresveratrol results in increased expression of ABCA1 mRNA; resveratrol results in increased expression of ABCA1 proteinPMID:16901463 PMID:20372816 PMID:23041272
Abca1multiple interactionsISOABCA1 (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of ABCA1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of ABCA1 protein]; [resveratrol results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol; ADORA2A protein promotes the reaction [resveratrol results in increased expression of ABCA1 protein]; PPARG protein promotes the reaction [resveratrol results in increased expression of ABCA1 mRNA]; PPARG protein promotes the reaction [resveratrol results in increased expression of ABCA1 protein]; ZM 241385 inhibits the reaction [resveratrol results in increased expression of ABCA1 protein]PMID:20372816 PMID:23041272
Go Back to source page   Continue to Ontology report