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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344 Species: Rattus norvegicus RGD Object: Gene Symbol: Abca1 Name: ATP-binding cassette, subfamily A (ABC1), member 1

Acc ID: CHEBI:17489 Term: 3',5'-cyclic AMP Definition: 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. CasRN: 60-92-4 Chemical ID: MESH:D000242

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1332354	6480464	CTD	Cyclic AMP results in increased expression of ABCA1 protein Cyclic AMP results in increased expression of ABCA1 mRNA	PMID:20339114
multiple interactions	ISO	RGD:1332354	6480464	CTD	[NIACR1 protein results in decreased abundance of Cyclic AMP] which results in decreased expression of ABCA1 protein	PMID:20655299