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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:15365
Term: acetylsalicylic acid
Definition: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Chemical ID: MESH:D001241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca1affects expressionISOAbca1 (Mus musculus)6480464CTDAspirin affects the expression of ABCA1 mRNAPMID:21088444
Abca1decreases expressionISOABCA1 (Homo sapiens)6480464CTDAspirin results in decreased expression of ABCA1 mRNAPMID:15037193
Abca1increases expressionISOABCA1 (Homo sapiens)6480464CTDAspirin results in increased expression of ABCA1 mRNA; Aspirin results in increased expression of ABCA1 proteinPMID:20137092
Abca1multiple interactionsISOAbca1 (Mus musculus)6480464CTDAspirin affects the expression of and affects the activity of ABCA1 protein; PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]; PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein]PMID:21088444
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