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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628827
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1d1
Name: nuclear receptor subfamily 1, group D, member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1d1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of NR1D1 mRNAPMID:22298810
Nr1d1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of NR1D1 mRNAPMID:21215274 PMID:32109520
Nr1d1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of NR1D1 mRNAPMID:33387578
Nr1d1affects expressionISONr1d1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NR1D1 mRNAPMID:21570461 PMID:24058054
Nr1d1decreases expressionISONr1d1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of NR1D1 mRNAPMID:26290441
Nr1d1increases expressionISONr1d1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of NR1D1 mRNAPMID:19933214 PMID:25975270 PMID:28213091
Nr1d1multiple interactionsISONr1d1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of NR1D1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NR1D1 gene]PMID:28213091 PMID:28433925
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