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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628748
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adipoq
Name: adiponectin, C1Q and collagen domain containing
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adipoqdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ADIPOQ mRNA; bisphenol A results in decreased expression of ADIPOQ proteinPMID:24472609 PMID:24705360 PMID:25181051 PMID:27806752 PMID:31661889 PMID:37570835
Adipoqincreases expressionEXP 6480464CTDbisphenol A results in increased expression of ADIPOQ mRNA; bisphenol A results in increased expression of ADIPOQ proteinPMID:17010207 PMID:20219716 PMID:32145629
Adipoqincreases secretionEXP 6480464CTDbisphenol A results in increased secretion of ADIPOQ proteinPMID:31697385
Adipoqmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of ADIPOQ mRNA; [bisphenol A co-treated with Testosterone] results in decreased expression of ADIPOQ mRNA; bisphenol A promotes the reaction [Fructose results in decreased expression of ADIPOQ protein]; bisphenol A results in decreased expression of and results in decreased secretion of ADIPOQ protein; Fructose promotes the reaction [bisphenol A results in decreased expression of ADIPOQ protein]; Resveratrol inhibits the reaction [bisphenol A results in decreased expression of ADIPOQ protein]PMID:26496021 PMID:31661889 PMID:32339907 PMID:36041667 PMID:37570835
Adipoqdecreases expressionISOADIPOQ (Homo sapiens)6480464CTDbisphenol A results in decreased expression of ADIPOQ mRNAPMID:23146750 PMID:27187765 PMID:32976960
Adipoqdecreases expressionISOAdipoq (Mus musculus)6480464CTDbisphenol A results in decreased expression of ADIPOQ mRNAPMID:18417718 PMID:30133442
Adipoqdecreases secretionISOADIPOQ (Homo sapiens)6480464CTDbisphenol A results in decreased secretion of ADIPOQ proteinPMID:19079714
Adipoqincreases expressionISOADIPOQ (Homo sapiens)6480464CTDbisphenol A results in increased expression of ADIPOQ proteinPMID:34186270
Adipoqincreases expressionISOAdipoq (Mus musculus)6480464CTDbisphenol A results in increased expression of ADIPOQ mRNA; bisphenol A results in increased expression of ADIPOQ proteinPMID:26996129 PMID:30959087 PMID:32156529
Adipoqincreases secretionISOADIPOQ (Homo sapiens)6480464CTDbisphenol A results in increased secretion of ADIPOQ proteinPMID:29223775
Adipoqmultiple interactionsISOADIPOQ (Homo sapiens)6480464CTDbisphenol A promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased secretion of ADIPOQ protein]PMID:31016361
Adipoqmultiple interactionsISOAdipoq (Mus musculus)6480464CTD[1-Methyl-3-isobutylxanthine co-treated with bisphenol A co-treated with INS protein] results in increased expression of ADIPOQ protein; bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; bisphenol A inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]; MAP2K3 protein inhibits the reaction [MIR21A mRNA inhibits the reaction [bisphenol A results in increased expression of ADIPOQ mRNA]]; MAP2K3 protein inhibits the reaction [MIR21A mRNA inhibits the reaction [bisphenol A results in increased expression of ADIPOQ protein]]; MIR21A mRNA inhibits the reaction [bisphenol A results in increased expression of ADIPOQ mRNA]; MIR21A mRNA inhibits the reaction [bisphenol A results in increased expression of ADIPOQ protein]PMID:22197818 PMID:26820058 PMID:26996129 PMID:33265944
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