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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628748
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adipoq
Name: adiponectin, C1Q and collagen domain containing
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adipoqmultiple interactionsEXP 6480464CTDADIPOQ protein inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; ADIPOQ protein inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; ADIPOQ protein inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; IL10 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]PMID:20052772 PMID:20861358
Adipoqdecreases response to substanceISOAdipoq (Mus musculus)6480464CTDADIPOQ results in decreased susceptibility to LipopolysaccharidesPMID:22156343
Adipoqincreases expressionISOAdipoq (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of ADIPOQ mRNAPMID:17641834
Adipoqincreases secretionISOAdipoq (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of ADIPOQ proteinPMID:17641834
Adipoqmultiple interactionsISOADIPOQ (Homo sapiens)6480464CTDADIPOQ inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]PMID:22156343
Adipoqmultiple interactionsISOAdipoq (Mus musculus)6480464CTDADIPOQ gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; ADIPOQ protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of CXCL10 mRNA]; ADIPOQ protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of HMOX1 protein]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT1 protein]; ADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; ADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; ADIPOR2 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; ADIPOR2 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; HMOX1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; HMOX1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of ADIPOQ mRNA]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of ADIPOQ protein]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]PMID:17641834 PMID:20861358 PMID:22156343
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