GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cd86 | affects expression | ISO | CD86 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides affects the expression of CD86 protein | PMID:24749687 | Cd86 | affects expression | ISO | Cd86 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides affects the expression of CD86 protein | PMID:24561310 | Cd86 | decreases expression | ISO | CD86 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in decreased expression of CD86 mRNA | PMID:18192897 | Cd86 | increases expression | ISO | CD86 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of CD86 mRNA; Lipopolysaccharides results in increased expression of CD86 protein | PMID:11884429 PMID:12538815 PMID:15135313 PMID:15246609 PMID:16299289 PMID:16890772 PMID:17698565 PMID:20417223 PMID:21362464 PMID:21742781 PMID:24136171 PMID:25725100 PMID:35781746 PMID:35811015 | Cd86 | increases expression | ISO | Cd86 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of CD86 mRNA; Lipopolysaccharides results in increased expression of CD86 protein | PMID:15618177 PMID:16890772 PMID:19148301 PMID:20348231 PMID:21945492 PMID:21948866 PMID:22024136 PMID:22916010 PMID:23376802 PMID:28499610 PMID:28811679 PMID:29338785 PMID:33049506 PMID:36762617 | Cd86 | multiple interactions | ISO | CD86 (Homo sapiens) | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; 2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester affects the reaction [Lipopolysaccharides affects the expression of CD86 protein]; 6-formylindolo(3,2-b)carbazole affects the reaction [Lipopolysaccharides affects the expression of CD86 protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD86 protein; [diethyl phthalate co-treated with Lipopolysaccharides] results in decreased expression of CD86 protein; [Ethinyl Estradiol co-treated with Lipopolysaccharides] results in increased expression of CD86 protein; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipopolysaccharides] results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with 6-formylindolo(3,2-b)carbazole] results in decreased expression of CD86 protein; [Lipopolysaccharides co-treated with Diethylstilbestrol] results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with Estradiol] results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with indole-3-carbinol] results in decreased expression of CD86 protein; [Lipopolysaccharides co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CD86 protein; [Lipopolysaccharides co-treated with Zearalenone] results in increased expression of CD86 protein; [perfluorooctane sulfonic acid co-treated with Lipopolysaccharides] results in decreased expression of CD86 protein; [Resveratrol co-treated with Lipopolysaccharides] results in increased expression of CD86 protein; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CD86 mRNA; CD86 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; CEP-11004 inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; CSF2 protein affects the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Flutamide inhibits the reaction [[Ethinyl Estradiol co-treated with Lipopolysaccharides] results in increased expression of CD86 protein]; Mifepristone inhibits the reaction [[diethyl phthalate co-treated with Lipopolysaccharides] results in decreased expression of CD86 protein]; Mifepristone inhibits the reaction [[perfluorooctane sulfonic acid co-treated with Lipopolysaccharides] results in decreased expression of CD86 protein]; MIR146A mRNA affects the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; NFE2L2 protein affects the reaction [Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]]; NFE2L2 protein affects the reaction [Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]]; Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein]; Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein] | PMID:12538815 PMID:15135313 PMID:15663903 PMID:16299289 PMID:16890772 PMID:17698565 PMID:24749687 PMID:25725100 PMID:27783115 PMID:32328699 PMID:35781746 PMID:35811015 PMID:36113621 | Cd86 | multiple interactions | ISO | Cd86 (Mus musculus) | 6480464 | CTD | 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA]]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; [IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with CSF2 protein] results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD86 protein; [Lipopolysaccharides co-treated with indole-3-carbinol] results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD86 protein; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]; cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]; daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Equol inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Genistein inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; indole-3-carbinol promotes the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein]; NOX4 protein affects the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; pyrithione inhibits the reaction [Lipopolysaccharides results in increased expression of CD86]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CD86 protein]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA]; VCE-003 analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA] | PMID:16081843 PMID:16890772 PMID:17126599 PMID:17512567 PMID:19148301 PMID:19172522 PMID:20348231 PMID:21097750 PMID:21945492 PMID:21948866 PMID:24561310 PMID:28811679 PMID:29338785 PMID:29689377 PMID:33049506 PMID:34352350 PMID:36762617 PMID:37019307 | | ||||||||||||||||||||||
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