GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptger4 | increases expression | ISO | PTGER4 (Homo sapiens) | 6480464 | CTD | nickel sulfate results in increased expression of PTGER4 mRNA | PMID:22714537 | Ptger4 | multiple interactions | ISO | PTGER4 (Homo sapiens) | 6480464 | CTD | [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP] | PMID:23526216 | | ||||||||||||||||||||||
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