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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621812
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:8040
Term: phalloidin
Definition: A homodetic bicyclic heptapeptide having a sulfide bridge.
Chemical ID: MESH:D010590
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3increases expressionISOCxcl3 (Mus musculus)6480464CTDPhalloidine results in increased expression of CXCL1 mRNAPMID:25280775
Cxcl3multiple interactionsISOCxcl3 (Mus musculus)6480464CTD[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of CXCL1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Phalloidine] which results in increased expression of CXCL1 mRNA; KEAP1 gene mutant form inhibits the reaction [Phalloidine results in increased expression of CXCL1 mRNA]; NFE2L2 gene mutant form promotes the reaction [Phalloidine results in increased expression of CXCL1 mRNA]; Oleanolic Acid inhibits the reaction [Phalloidine results in increased expression of CXCL1 mRNA]PMID:25280775
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