GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cxcl3 | increases expression | EXP | | 6480464 | CTD | Ozone results in increased expression of CXCL3 mRNA | PMID:16716893 PMID:26667333 | Cxcl3 | decreases expression | ISO | Cxcl3 (Mus musculus) | 6480464 | CTD | Ozone results in decreased expression of CXCL1 mRNA | PMID:20123758 | Cxcl3 | increases expression | ISO | CXCL1 (Homo sapiens) | 6480464 | CTD | Ozone results in increased expression of CXCL1 mRNA | PMID:31476115 | Cxcl3 | increases expression | ISO | Cxcl3 (Mus musculus) | 6480464 | CTD | Ozone results in increased expression of CXCL1 mRNA; Ozone results in increased expression of CXCL1 protein; Ozone results in increased expression of CXCL3 mRNA | PMID:11463606 PMID:11777981 PMID:12794034 PMID:14701711 PMID:14754758 PMID:15361358 PMID:15371095 PMID:15516495 PMID:16002559 PMID:16373670 PMID:17095637 PMID:17460151 PMID:17575079 PMID:17626835 PMID:18007984 PMID:18417511 PMID:19059883 PMID:21543283 PMID:25658374 PMID:26342085 PMID:26752192 PMID:28533327 PMID:29471542 PMID:30848106 PMID:33026818 PMID:34175951 PMID:35201360 PMID:35928613 | Cxcl3 | increases secretion | ISO | Cxcl3 (Mus musculus) | 6480464 | CTD | Ozone results in increased secretion of CXCL1 protein | PMID:31626304 PMID:36376488 | Cxcl3 | multiple interactions | ISO | CXCL1 (Homo sapiens) | 6480464 | CTD | [Aripiprazole co-treated with Ozone] results in increased expression of CXCL1 mRNA | PMID:31476115 | Cxcl3 | multiple interactions | ISO | Cxcl3 (Mus musculus) | 6480464 | CTD | 3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Ozone results in increased expression of and results in increased secretion of CXCL1 protein]; 3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; 3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; [[Air Pollutants results in increased abundance of Ozone] which co-treated with Ovalbumin] results in increased expression of CXCL1 mRNA; [Acetaminophen co-treated with Ozone] results in increased expression of CXCL1 mRNA; [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of CXCL1 mRNA; [Air Pollutants results in increased abundance of Ozone] which affects the expression of CXCL1 protein; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CXCL1 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CXCL1 protein; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CXCL3 mRNA; [alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]]; [CPE affects the susceptibility to Ozone] which affects the expression of CXCL1 protein; [LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CXCL1 protein; [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in increased expression of CXCL3 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of CXCL3 mRNA; [Ovalbumin co-treated with Ozone] results in increased expression of CXCL1 mRNA; [Ovalbumin co-treated with Ozone] results in increased expression of CXCL1 protein; [Ozone co-treated with Acetaminophen] results in increased expression of CXCL1 protein; [Ozone co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein; [SFTPD protein results in decreased susceptibility to Ozone] which affects the secretion of CXCL1 protein; [Soot co-treated with Ozone] results in increased expression of CXCL1 mRNA; [Vehicle Emissions results in increased abundance of Ozone] which results in increased expression of CXCL1 mRNA; A 967079 inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; ADIPOQ protein inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of CXCL1 protein]; CPE gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]; CR1L protein affects the reaction [Ozone results in increased expression of CXCL1 protein]; IL13 protein affects the reaction [Ozone results in increased expression of CXCL1 mRNA]; IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CXCL1 protein]; IL1RN protein inhibits the reaction [Ozone results in increased expression of CXCL1 protein]; LEP gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]; LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]; MMP9 gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 mRNA]; MMP9 gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]; MYD88 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; NGF protein promotes the reaction [Ozone results in increased expression of CXCL1 protein]; NQO1 protein promotes the reaction [Ozone results in increased expression of CXCL1 protein]; Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]; Ozone results in increased expression of and results in increased secretion of CXCL1 protein; sodium bisulfide inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of CXCL1 protein]; TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; TLR4 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; TNFRSF1A affects the reaction [[Air Pollutants results in increased abundance of Ozone] which affects the expression of CXCL1 protein] | PMID:11463606 PMID:12794034 PMID:14701711 PMID:14754758 PMID:16002559 PMID:16373670 PMID:17626835 PMID:18007984 PMID:18417511 PMID:18929643 PMID:19059883 PMID:20123758 PMID:21355040 PMID:22066571 PMID:22474022 PMID:23019345 PMID:23434795 PMID:24188200 PMID:25010831 PMID:25287866 PMID:25658374 PMID:26203683 PMID:26752192 PMID:27106289 PMID:27472835 PMID:29284473 PMID:34760922 PMID:34911549 PMID:35928613 PMID:36303316 PMID:36376488 | | ||||||||||||||||||||||
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