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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621812
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3multiple interactionsEXP 6480464CTD[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of CXCL3 mRNAPMID:33729688
Cxcl3increases expressionISOCxcl3 (Mus musculus)6480464CTDOxygen results in increased expression of CXCL1 mRNAPMID:22363622
Cxcl3multiple interactionsISOCxcl3 (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CXCL1 mRNA; [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of CXCL3 mRNA; [Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CXCL1 protein; [POSTN gene mutant form results in decreased susceptibility to Oxygen] which results in decreased expression of CXCL1 mRNA; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CXCL1 protein]; PARP1 gene mutant form inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CXCL1 protein]; POSTN gene mutant form inhibits the reaction [Oxygen results in increased expression of CXCL1 mRNA]PMID:15696051 PMID:22363622 PMID:30529165
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