GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Park7 | decreases activity | ISO | PARK7 (Homo sapiens) | 6480464 | CTD | Paraquat results in decreased activity of PARK7 protein | PMID:36842454 | Park7 | decreases expression | ISO | Park7 (Mus musculus) | 6480464 | CTD | Paraquat results in decreased expression of PARK7 mRNA | PMID:36108500 | Park7 | increases expression | ISO | PARK7 (Homo sapiens) | 6480464 | CTD | Paraquat results in increased expression of PARK7 protein; Paraquat results in increased expression of PARK7 protein alternative form | PMID:11697128 PMID:11811539 PMID:14662519 | Park7 | increases response to substance | ISO | Park7 (Mus musculus) | 6480464 | CTD | PARK7 protein results in increased susceptibility to Paraquat | PMID:21300143 | Park7 | multiple interactions | ISO | PARK7 (Homo sapiens) | 6480464 | CTD | 3-(4-(morpholin-4-yl)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile inhibits the reaction [[Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein]; [Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Paraquat results in increased sulfation of and results in increased oxidation of PARK7 protein]; Meloxicam inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]; Paraquat promotes the reaction [Quinones binds to PARK7 protein]; Paraquat results in increased sulfation of and results in increased oxidation of PARK7 protein; PARK7 protein inhibits the reaction [Paraquat promotes the reaction [TARDBP protein binds to TARDBP protein]]; Plant Extracts inhibits the reaction [[Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein] | PMID:20851755 PMID:26409479 PMID:30372676 PMID:34897981 | Park7 | multiple interactions | ISO | Park7 (Mus musculus) | 6480464 | CTD | PARK7 gene mutant form affects the reaction [Paraquat affects the expression of NFE2L2 protein]; PARK7 gene mutant form affects the reaction [Paraquat affects the expression of PSMB5 protein]; PARK7 gene mutant form affects the reaction [Paraquat affects the expression of PSMC5 protein]; PARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides]; PARK7 protein affects the reaction [Paraquat results in increased cleavage of CASP3 protein]; PARK7 protein affects the reaction [Paraquat results in increased cleavage of PARP1 protein] | PMID:17823202 PMID:21300143 | | ||||||||||||||||||||||
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