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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621776
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stc1
Name: stanniocalcin 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stc1increases expressionISOSTC1 (Homo sapiens)6480464CTDEstradiol results in increased expression of STC1 mRNA; Estradiol results in increased expression of STC1 proteinPMID:18191855 PMID:28711546 PMID:31614463
Stc1multiple interactionsISOSTC1 (Homo sapiens)6480464CTD4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]; [Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of STC1 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of STC1 mRNA; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]; pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]; U 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA]PMID:17404688 PMID:20660070 PMID:30165855
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