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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases expressionISOGSR (Homo sapiens)6480464CTDmanganese chloride results in decreased expression of GSR mRNAPMID:17175027
Gsrdecreases expressionISOGsr (Mus musculus)6480464CTDmanganese chloride results in decreased expression of GSR proteinPMID:24969583 PMID:25288107
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTD[manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein]PMID:24969583 PMID:25288107 PMID:32445656
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