Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:53444
Term: potassium dichromate
Definition: A potassium salt that is the dipotassium salt of dichromic acid.
Chemical ID: MESH:D011192
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDPotassium Dichromate results in decreased activity of GSR proteinPMID:1512015 PMID:15854231 PMID:20203132 PMID:22115772 PMID:23470461 PMID:9194422 PMID:9492363
Gsrdecreases expressionEXP 6480464CTDPotassium Dichromate results in decreased expression of GSR mRNA; Potassium Dichromate results in decreased expression of GSR proteinPMID:23470461 PMID:30578656
Gsrmultiple interactionsEXP 6480464CTD[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased activity of GSR protein; Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]; Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSR mRNA]; Deferoxamine inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]; Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]; Plant Extracts inhibits the reaction [Fenitrothion promotes the reaction [Potassium Dichromate results in decreased expression of GSR protein]]; Plant Extracts inhibits the reaction [Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]]; Plant Extracts inhibits the reaction [Potassium Dichromate results in decreased expression of GSR protein]; Potassium Dichromate promotes the reaction [Fenitrothion results in decreased expression of GSR protein]; Potassium Dichromate promotes the reaction [GSR protein results in increased oxidation of NADP]; S-allylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased activity of GSR protein]PMID:19167472 PMID:22115772 PMID:23470461 PMID:28988497 PMID:30578656
Gsrdecreases activityISOGSR (Homo sapiens)6480464CTDPotassium Dichromate results in decreased activity of GSR proteinPMID:21681464 PMID:29665407
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTDprotocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]PMID:29665407
Go Back to source page   Continue to Ontology report