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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsraffects expressionEXP 6480464CTDChlorpyrifos affects the expression of GSR mRNAPMID:17452286
Gsrdecreases activityEXP 6480464CTDChlorpyrifos results in decreased activity of GSR proteinPMID:23172834
Gsrdecreases expressionEXP 6480464CTDChlorpyrifos results in decreased expression of GSR mRNA; Chlorpyrifos results in decreased expression of GSR proteinPMID:31823260
Gsrmultiple interactionsEXP 6480464CTDBerberine inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein]; Glutathione inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Chlorpyrifos results in decreased expression of GSR mRNA]; Plant Extracts inhibits the reaction [Chlorpyrifos results in decreased expression of GSR protein]PMID:23172834 PMID:31823260 PMID:35439518
Gsrdecreases activityISOGsr (Mus musculus)6480464CTDChlorpyrifos results in decreased activity of GSR proteinPMID:32798940
Gsrdecreases expressionISOGsr (Mus musculus)6480464CTDChlorpyrifos results in decreased expression of GSR mRNAPMID:37019170
Gsrincreases expressionISOGSR (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of GSR mRNAPMID:23850137
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTD[cypermethrin co-treated with Chlorpyrifos] results in decreased activity of GSR protein; Plant Extracts inhibits the reaction [[cypermethrin co-treated with Chlorpyrifos] results in decreased activity of GSR protein]PMID:15991261
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