GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gsr | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of GSR mRNA | PMID:24634002 | Gsr | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [Arsenic Trioxide inhibits the reaction [GSR protein results in increased oxidation of NADP]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of GSR mRNA]; Arsenic Trioxide inhibits the reaction [GSR protein results in increased oxidation of NADP]; Arsenic Trioxide inhibits the reaction [GSR protein results in increased reduction of Glutathione Disulfide]; Arsenic Trioxide promotes the reaction [GSR protein binds to Glutathione Disulfide]; Arsenic Trioxide results in increased expression of and results in decreased activity of GSR protein; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased expression of GSR mRNA]; GSR protein inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein] | PMID:24634002 | Gsr | decreases activity | ISO | Gsr (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of GSR protein | PMID:18715643 PMID:25542264 | Gsr | decreases response to substance | ISO | GSR (Homo sapiens) | 6480464 | CTD | GSR protein results in decreased susceptibility to Arsenic Trioxide | PMID:20707922 | Gsr | increases expression | ISO | GSR (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of GSR mRNA | PMID:17258074 PMID:19417148 | Gsr | multiple interactions | ISO | GSR (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GSR mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GSR protein; [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of GSR mRNA | PMID:30012499 PMID:33434570 | Gsr | multiple interactions | ISO | Gsr (Mus musculus) | 6480464 | CTD | Ascorbic Acid inhibits the reaction [Arsenic Trioxide results in decreased activity of GSR protein]; beta Carotene inhibits the reaction [Arsenic Trioxide results in decreased activity of GSR protein] | PMID:18715643 PMID:25542264 | | ||||||||||||||||||||||
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