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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:30314
Term: (R)-lipoic acid
Definition: The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrmultiple interactionsEXP 6480464CTDThioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]PMID:19699728 PMID:22623521 PMID:27581792
Gsrincreases expressionISOGSR (Homo sapiens)6480464CTDThioctic Acid results in increased expression of GSR mRNAPMID:23649336
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTDThioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]PMID:32061150
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