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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDCopper results in decreased activity of GSR proteinPMID:22127830
Gsrmultiple interactionsEXP 6480464CTD[aminoacetone co-treated with Copper] results in increased expression of GSR mRNA; zinc chloride inhibits the reaction [Copper results in decreased activity of GSR protein]PMID:18729331 PMID:20600438
Gsraffects bindingISOGSR (Homo sapiens)6480464CTDGSR protein binds to CopperPMID:15359738
Gsrdecreases activityISOGsr (Mus musculus)6480464CTDCopper analog results in decreased activity of GSR proteinPMID:21319953 PMID:22000994
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTD[Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of GSR mRNAPMID:35809665
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