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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:28527
Term: rutin
Definition: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups.
Chemical ID: MESH:D012431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrmultiple interactionsEXP 6480464CTDRutin inhibits the reaction [Cisplatin results in decreased expression of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]PMID:21605616 PMID:25753322
Gsrdecreases activityISOGSR (Homo sapiens)6480464CTDRutin results in decreased activity of GSR proteinPMID:15782287
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