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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:18248
Term: iron atom
Definition: An iron group element atom that has atomic number 26.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsraffects activityEXP 6480464CTDIron affects the activity of GSR proteinPMID:24388910
Gsrdecreases expressionEXP 6480464CTDIron results in decreased expression of GSR proteinPMID:20020847 PMID:35247364
Gsrmultiple interactionsEXP 6480464CTD[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein; leonurine inhibits the reaction [Iron results in decreased expression of GSR protein]PMID:17176674 PMID:35247364
Gsrdecreases activityISOGsr (Mus musculus)6480464CTDIron results in decreased activity of GSR proteinPMID:12504893
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTD[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GSR protein; Iron deficiency inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein]; Iron promotes the reaction [Benzoyl Peroxide results in decreased activity of GSR protein]; Iron promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]PMID:12067571 PMID:12504893 PMID:33393188
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