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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:17858
Term: glutathione disulfide
Definition: A glutathione derivative that has formula C20H32N6O12S2.
Chemical ID: MESH:D019803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrmultiple interactionsEXP 6480464CTDarsenic trioxide inhibits the reaction [GSR protein results in increased reduction of Glutathione Disulfide]; arsenic trioxide promotes the reaction [GSR protein binds to Glutathione Disulfide]; GSR protein binds to and results in increased reduction of Glutathione DisulfidePMID:24634002
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTDGlutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]PMID:19668867
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTD[[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione DisulfidePMID:12114195 PMID:12477282
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