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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159 Species: Mus musculus RGD Object: Gene Symbol: Casp9 Name: caspase 9

Acc ID: CHEBI:34873 Term: N-nitrosodiethylamine Definition: A nitrosamine that has formula C4H10N2O. CasRN: 55-18-5 Chemical ID: MESH:D004052

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Diethylnitrosamine results in increased expression of CASP9 mRNA	PMID:18691550
multiple interactions	EXP		6480464	CTD	MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CASP9 mRNA]	PMID:18691550
decreases expression	ISO	RGD:61867	6480464	CTD	Diethylnitrosamine results in decreased expression of CASP9 protein	PMID:19931519
multiple interactions	ISO	RGD:61867	6480464	CTD	morin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP9 protein]	PMID:19931519
multiple interactions	ISO	RGD:61867	6480464	CTD	[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein] geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA]	PMID:21907755