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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621511
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctsd
Name: cathepsin D
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsdincreases expressionISOCTSD (Homo sapiens)6480464CTDTamoxifen results in increased expression of CTSD mRNA; Tamoxifen results in increased expression of CTSD proteinPMID:15149724
Ctsdmultiple interactionsISOCTSD (Homo sapiens)6480464CTDbenzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]; Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]PMID:17157789
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