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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621511
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctsd
Name: cathepsin D
Acc ID: CHEBI:31905
Term: nicorandil
Definition: A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris.
Chemical ID: MESH:D020108
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctsdmultiple interactionsEXP 6480464CTD[Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]PMID:11829124 PMID:14499179
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