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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621481
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt2
Name: sirtuin 2
Acc ID: CHEBI:73158
Term: sirtinol
Definition: A benzamide obtained by formal condensation of the carboxy group of 2-{[(2-hydroxy-1-naphthyl)methylene]amino}benzoic acid with the amino group of 1-phenylethylamine.
Chemical ID: MESH:C439060
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt2decreases activityISOSIRT2 (Homo sapiens)6480464CTDsirtinol analog results in decreased activity of SIRT2 protein; sirtinol results in decreased activity of SIRT2 proteinPMID:16302818 PMID:24998427
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