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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases activityISONr1i3 (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased activity of NR1I3 proteinPMID:17964624
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether affects the localization of and results in increased activity of NR1I3 protein; [2,2',4,4'-tetrabromodiphenyl ether results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNAPMID:24218150
Nr1i3multiple interactionsISONr1i3 (Mus musculus)6480464CTDNR1I3 protein affects the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP2B10 mRNA]PMID:24218150
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