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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351 Species: Rattus norvegicus RGD Object: Gene Symbol: Col1a2 Name: collagen, type I, alpha 2

Acc ID: CHEBI:15343 Term: acetaldehyde Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. CasRN: 75-07-0 Chemical ID: MESH:D000079

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:730985	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:8660697 PMID:10729205 PMID:7768510 PMID:15130784 PMID:8294106 PMID:10069557 PMID:9143363
increases expression	ISO	RGD:730985	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:10729205 PMID:7768510 PMID:15130784 PMID:10069557 PMID:8294106 PMID:8660697 PMID:9143363
multiple interactions	ISO	RGD:730984	6480464	CTD	4-hydroxymercuribenzoate inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] Sirolimus inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] calphostin C inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] PD 98059 inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	PMID:11343241
increases expression	ISO	RGD:730984	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:16025520 PMID:11343241
multiple interactions	ISO	RGD:730984	6480464	CTD	SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] SMAD4 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	PMID:16025520
multiple interactions	ISO	RGD:730985	6480464	CTD	Acetaldehyde promotes the reaction [NFIC protein binds to COL1A2 promoter] NFIC protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	PMID:7768510
increases expression	ISO	RGD:730985	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:10729205 PMID:10069557 PMID:9143363 PMID:15130784 PMID:8660697 PMID:8294106 PMID:7768510
multiple interactions	ISO	RGD:730985	6480464	CTD	LEP protein affects the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	PMID:15130784
multiple interactions	ISO	RGD:730985	6480464	CTD	calphostin C inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] tricyclodecane-9-yl-xanthogenate inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	PMID:10069557
multiple interactions	ISO	RGD:730985	6480464	CTD	Tretinoin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]	PMID:10729205
increases expression	ISO	RGD:730984	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:11343241 PMID:16025520
increases expression	ISO	RGD:730985	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:10729205 PMID:10069557 PMID:8294106 PMID:8660697 PMID:15130784 PMID:9143363 PMID:7768510
increases expression	ISO	RGD:730985	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:8294106 PMID:15130784 PMID:9143363 PMID:10729205 PMID:10069557 PMID:8660697 PMID:7768510
increases expression	ISO	RGD:730985	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:8294106 PMID:15130784 PMID:8660697 PMID:10729205 PMID:10069557 PMID:7768510 PMID:9143363
increases expression	ISO	RGD:730985	6480464	CTD	Acetaldehyde results in increased expression of COL1A2 mRNA	PMID:10069557 PMID:10729205 PMID:15130784 PMID:7768510 PMID:8294106 PMID:8660697 PMID:9143363