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GENE - TERM ANNOTATION REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: DOID:9004009
Term: Reperfusion Injury
Definition: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Definition Source(s): MESH:D015427
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9 IMP 5129531RGDassociated with lung injury; mRNA, protein:increased expression:lung 
Mmp9 ISOMmp9 (Mus musculus)1582618RGD  
Mmp9 ISOMmp9 (Mus musculus)1582631RGDprotein:increased expression:limb muscle (mouse) 
Mmp9 ISOMMP9 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:23075401
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