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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDPioglitazone results in decreased expression of MMP9 mRNAPMID:30031879
Mmp9decreases secretionISOMMP9 (Homo sapiens)6480464CTDpioglitazone results in decreased secretion of MMP9 proteinPMID:16860414
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [pioglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]]; pioglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]PMID:17055343
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