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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:50845
Term: doxycycline
Definition: Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
Chemical ID: MESH:D004318
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases activityEXP 6480464CTDDoxycycline results in decreased activity of MMP9 proteinPMID:20837116
Mmp9multiple interactionsEXP 6480464CTDDoxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein]PMID:20837116
Mmp9decreases expressionISOMmp9 (Mus musculus)6480464CTDDoxycycline results in decreased expression of MMP9 proteinPMID:18178469
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDDoxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]PMID:17498959 PMID:19375915
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDDoxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]PMID:15131573 PMID:18089841
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