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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionEXP 6480464CTDPaclitaxel results in increased expression of MMP9 mRNAPMID:35921949
Mmp9multiple interactionsEXP 6480464CTDHesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP9 mRNA]PMID:35921949
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDPaclitaxel results in increased expression of MMP9 proteinPMID:36898573
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTD[Cisplatin co-treated with Paclitaxel] results in increased expression of MMP9 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]PMID:16243823 PMID:20705681
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDTrimetazidine inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]PMID:36898573
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