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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionEXP 6480464CTDvorinostat results in increased expression of MMP9 mRNAPMID:20060208
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDvorinostat results in decreased expression of MMP9 mRNA; vorinostat results in decreased expression of MMP9 proteinPMID:19509267 PMID:26238599
Mmp9decreases secretionISOMMP9 (Homo sapiens)6480464CTDvorinostat results in decreased secretion of MMP9 proteinPMID:20421217
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDvorinostat inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; vorinostat inhibits the reaction [TNF protein results in increased expression of MMP9 protein]PMID:16377638 PMID:27163855
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