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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionEXP 6480464CTDMethotrexate results in increased expression of MMP9 mRNAPMID:29935243
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDMethotrexate results in increased expression of MMP9 mRNAPMID:17696278
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTD[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of MMP9 mRNA; [Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of MMP9 proteinPMID:23146660
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