Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases activityEXP 6480464CTDDiethylnitrosamine results in increased activity of MMP9 proteinPMID:19052882
Mmp9increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of MMP9 proteinPMID:19539802
Mmp9multiple interactionsEXP 6480464CTD2-aminofluorene promotes the reaction [Diethylnitrosamine results in increased activity of MMP9 protein]; [Diethylnitrosamine co-treated with 2-aminofluorene] results in increased expression of MMP9 protein; bacoside A inhibits the reaction [Diethylnitrosamine results in increased expression of and results in increased activity of MMP9 protein]; Diethylnitrosamine results in increased expression of and results in increased activity of MMP9 protein; morin inhibits the reaction [Diethylnitrosamine results in increased expression of MMP9 protein]PMID:19052882 PMID:19539802 PMID:20084675
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of MMP9 mRNA; Diethylnitrosamine results in increased expression of MMP9 proteinPMID:16284949
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTD[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased expression of MMP9 protein; CCL3 protein affects the reaction [Diethylnitrosamine results in increased expression of MMP9 mRNA]; CCL3 protein affects the reaction [Diethylnitrosamine results in increased expression of MMP9 protein]; CCR1 protein affects the reaction [Diethylnitrosamine results in increased expression of MMP9 mRNA]; CCR1 protein affects the reaction [Diethylnitrosamine results in increased expression of MMP9 protein]; Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of MMP9 mRNA]; scoparone affects the reaction [[Dietary Fats co-treated with Dietary Sugars co-treated with Diethylnitrosamine] results in increased expression of MMP9 protein]; scoparone inhibits the reaction [Diethylnitrosamine promotes the reaction [[Dietary Fats co-treated with Dietary Sugars] results in increased expression of MMP9 mRNA]]PMID:16284949 PMID:37436232
Go Back to source page   Continue to Ontology report