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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of MMP9 mRNA; Benzo(a)pyrene results in increased expression of MMP9 proteinPMID:19022365 PMID:21467743
Mmp9multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]PMID:19022365
Mmp9affects expressionISOMMP9 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of MMP9 mRNAPMID:31154059
Mmp9affects expressionISOMmp9 (Mus musculus)6480464CTDBenzo(a)pyrene affects the expression of MMP9 mRNAPMID:22342234
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of MMP9 mRNAPMID:20106945 PMID:30659931
Mmp9decreases expressionISOMmp9 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of MMP9 mRNAPMID:20713471
Mmp9increases activityISOMMP9 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased activity of MMP9 proteinPMID:15922868
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of MMP9 mRNA; Benzo(a)pyrene results in increased expression of MMP9 proteinPMID:15922868 PMID:25724548 PMID:26359795 PMID:31778776 PMID:35870112
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of MMP9 mRNAPMID:22369883
Mmp9increases methylationISOMMP9 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of MMP9 promoterPMID:27901495
Mmp9increases methylationISOMmp9 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of MMP9 exon; Benzo(a)pyrene results in increased methylation of MMP9 intronPMID:27901495
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDLINC00673 affects the reaction [Benzo(a)pyrene results in increased expression of MMP9 protein]; U 0126 inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]PMID:25724548 PMID:31778776
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDbaicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]PMID:22369883
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