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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [Doxorubicin results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]PMID:16213474
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [mangostin analog results in decreased expression of MMP2 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in decreased expression of MMP2]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]; pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of MMP2 protein]; pyrazolanthrone promotes the reaction [dehydrocrenatidine results in decreased expression of MMP2 protein]; pyrazolanthrone promotes the reaction [Resveratrol results in decreased expression of and results in decreased activity of MMP2 protein]PMID:20599481 PMID:24841706 PMID:25605016 PMID:27060453 PMID:28722351 PMID:34076342
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTDpyrazolanthrone inhibits the reaction [Particulate Matter results in increased methylation of MMP2 promoter]PMID:22355787
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