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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of MMP2 mRNAPMID:34747641
Mmp2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of MMP2 mRNAPMID:33387578
Mmp2affects expressionISOMMP2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of MMP2 mRNAPMID:22574217
Mmp2decreases expressionISOMmp2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of MMP2 mRNAPMID:22666406 PMID:24035824 PMID:26290441 PMID:33956508
Mmp2increases activityISOMMP2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased activity of MMP2 proteinPMID:24469321
Mmp2increases activityISOMmp2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased activity of MMP2 proteinPMID:24154488
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of MMP2; Tetrachlorodibenzodioxin results in increased expression of MMP2 mRNAPMID:17003102 PMID:19147701
Mmp2increases expressionISOMmp2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of MMP2 mRNAPMID:14728982 PMID:24154488
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP2 mRNA]; AG 1879 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP2 mRNA]; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP2 mRNA]; EGTA acetoxymethyl ester inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP2 mRNA]; methyl arachidonylfluorophosphonate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP2 mRNA]; MMP1 protein affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MMP2 protein]; Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of MMP2 proteinPMID:15982688 PMID:19147701 PMID:24469321
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTDAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP2 mRNA]PMID:14728982
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