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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityEXP 6480464CTDQuercetin results in decreased activity of MMP2 proteinPMID:21362404
Mmp2multiple interactionsEXP 6480464CTD[Quercetin co-treated with Carbon Tetrachloride] results in increased expression of MMP2 mRNA; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 protein]; Quercetin promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]PMID:22989100 PMID:26476374
Mmp2affects activityISOMMP2 (Homo sapiens)6480464CTDQuercetin affects the activity of MMP2 proteinPMID:22871832
Mmp2affects expressionISOMMP2 (Homo sapiens)6480464CTDQuercetin affects the expression of MMP2 mRNAPMID:22871832 PMID:32530119
Mmp2decreases activityISOMmp2 (Mus musculus)6480464CTDQuercetin results in decreased activity of MMP2 proteinPMID:24275163
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDQuercetin results in decreased expression of MMP2 proteinPMID:27279714
Mmp2decreases expressionISOMmp2 (Mus musculus)6480464CTDQuercetin results in decreased expression of MMP2 mRNAPMID:24275163
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDQuercetin affects the activity of and affects the secretion of MMP2 protein; Quercetin affects the expression of and results in decreased secretion of MMP2 protein; Quercetin inhibits the reaction [IL1B protein results in increased expression of MMP2 protein]; Quercetin inhibits the reaction [IL6 protein results in increased secretion of MMP2 protein]; Quercetin inhibits the reaction [Phosphatidic Acids results in increased activity of MMP2 protein]; Quercetin promotes the reaction [prolinedithiocarbamate results in decreased expression of MMP2 protein]; Quercetin promotes the reaction [TLR4 protein affects the expression of MMP2 protein]; Quercetin results in decreased expression of and results in decreased activity of MMP2 protein; Tamoxifen affects the reaction [Quercetin affects the expression of MMP2 mRNA]PMID:21867678 PMID:22394507 PMID:22871832 PMID:23645742 PMID:24001813 PMID:26408079 PMID:27279714 PMID:32530119
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTDQuercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 protein]PMID:22728078 PMID:24337353
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