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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionEXP 6480464CTDTretinoin results in decreased expression of MMP2 mRNAPMID:21274875
Mmp2increases expressionEXP 6480464CTDTretinoin results in increased expression of MMP2 mRNAPMID:20488242
Mmp2multiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [Doxorubicin results in decreased expression of MMP2 mRNA]; Tretinoin inhibits the reaction [Doxorubicin results in decreased expression of MMP2 protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of MMP2 mRNA]PMID:19357873 PMID:21274875
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDTretinoin results in decreased activity of MMP2 proteinPMID:24374174
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDTretinoin results in decreased expression of MMP2 mRNAPMID:21924320 PMID:24374174 PMID:33167477
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDTretinoin results in increased expression of MMP2 mRNAPMID:16249480
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDTretinoin inhibits the reaction [TGFB1 results in increased activity of MMP2 protein]; Tretinoin inhibits the reaction [TGFB1 results in increased expression of MMP2 mRNA]PMID:21274875
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of MMP2 mRNA; [bisphenol F co-treated with Tretinoin] results in decreased expression of MMP2 mRNA; [bisphenol S co-treated with Tretinoin] results in decreased expression of MMP2 mRNAPMID:30951980
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